Search Results - biotech+%26+pharmaceutical

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Stent Nanocoatings with Controlled Drug Release and Improved Biocompatibility

BACKGROUND Industrial biopharmaceutical cell culture necessitates an expensive and risky scale-up process to get production scale volumes in order to manufacture proteins and other biopharmaceutical products. Traditional stirred single-use bioreactor bags can only scale to a five-fold maximum, but scaling for production requires several thousand...

Published: 5/12/2022 | Updated: 5/12/2022 | Inventor(s): Bin Zhi, Yu Mao

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Material Science, Technology Classifications > Medical Device & Diagnostic

Preparation of Melanin-inspired Antimicrobials

BACKGROUND Bacterial resistance to antibiotics is a serious worldwide health problem, which presents the risk of increased infection and uncontrolled transmission. Antibiotic resistance due to the misuse of drugs has genetically selected for the survival of resistant bacterial strains. This renders established antibiotic treatments ineffective against...

Published: 5/12/2022 | Updated: 2/8/2022 | Inventor(s): Santosh Adhikari, Toby Nelson

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Chemistry, Technology Classifications > Biotech & Pharmaceutical

Engineering Mesenchymal Stem Cells for COPD Therapy

Engineering Stem Cells for Pulmonary Disease Therapy OSU 2016-003 and 2016-004 BACKGROUND The discovery of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have resulted in a plethora of opportunities to produce tissue-specific cell types for disease modeling, drug screening and treatments for diseases. For pulmonary diseases...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Li Zhang, Lin Liu

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Engineered Respiratory Syncytial Viruses with Control of Cell-to-Cell Virus Transmission for Enhanced Safety of Live Virus Vaccines

ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES FOR SAFE LIVE VIRUS VACCINES (OSU Ref # 2011-036) BACKGROUND Respiratory Syncytial Virus (RSV) is the largest viral cause of pediatric bronchiolitis worldwide, a respiratory disease that results in over 100,000 deaths per year. RSV can also cause adult lung diseases such as pneumonia and poses a serious risk...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Antonius (Tom) Oomens

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Metabolites of SHetA2 as Anti-Cancer Agents

BACKGROUND SHetA2 has previously been identified by OSU researchers as a strong anti-cancer agent that induces apoptosis (cell death) in 8 different types of kidney cancer cells and is being developed for treatment of Polycystic Kidney Disease (PKD). SHetA2 is in the final stages of preclinical testing and since no toxicity to normal cells has been...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Doris Benbrook, Richard Bunce, Kenneth Berlin

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Use of the Salmonella spp type III secretion proteins as protective vaccine candidate

BACKGROUND Bacterial species belonging to the genus Salmonella are the leading cause of foodborne illness worldwide, inducing approximately 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths in the U.S. annually. Unfortunately, researchers have encountered several roadblocks in the quest for a safe, effective means of treating or preventing...

Published: 5/17/2022 | Updated: 2/8/2022 | Inventor(s): William Picking, Wendy Picking

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Method and component of a novel antiviral targeting type 1 interferon response

BACKGROUND Influenza virus infection results in 200,000 hospitalizations, 36,000 deaths, and $87 billion in healthcare costs per year in the U.S. The current treatments, which consist of antiviral drugs that target viral proteins, only work if new strains of influenza virus do not emerge. However, influenza viral proteins readily mutate to create new,...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Yujie Guo, Lin Liu

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Cofactor-free, Inexpensive, Rapid Liver Microsomal Bioreactor for Examining Drug Metabolism and Inhibition and Green Synthesis of Drug Metabolites

BACKGROUND Liver microsomes (LMs) are useful for biosensing, catalytic applications and drug development because of their ability to catalyze a broad range of reactions with inherent stereoselectivity. Using traditional LMs, expensive cofactors, such as NADPH must be added to facilitate metabolic reactions. Previous researchers have demonstrated that...

Published: 5/12/2022 | Updated: 2/8/2022 | Inventor(s): Sadagopan Krishnan

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Engineering Induced Pluripotent Stem Cells for COPD Therapy

BACKGROUND The discovery of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have resulted in a plethora of opportunities to produce tissue-specific cell types for disease modeling, drug screening and treatments for diseases. For pulmonary diseases such as COPD, stem cells have been a proposed strategy to repair damaged lungs....

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Li Zhang, Lin Liu

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Tissue Repair Devices and Scaffolds

BACKGROUND In orthopedics, it is often necessary to repair or replace damaged or degenerating bone. Multiphasic, three-dimensionally printed, tissue repair device (M3DRD) scaffolds have emerged as a replacement to current bone grafting techniques, all of which have serious drawbacks and cannot be produced in the elaborate designs and shapes necessary...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Van Thompson, Elizabeth Clark, John Ricci, Paulo Coelho, James Smay

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

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