Latest technologies from Oklahoma State University

Host Defense Peptide-inducing Compounds as Alternatives to Antibiotics

cowboyinnovations@okstate.edu — Thu, 12 May 2022 13:09:48 GMT

BACKGROUND Microbial resistance to antibiotics is a serious worldwide health problem, which presents the risk of increased infection and uncontrolled transmission. Unfortunately, one of the drivers for this resistance is overuse of antibiotics, which genetically selects for the survival of resistant strains. This occurs especially in the animal production sector, where livestock is administered with antibiotics as a group to prevent illness and curb infection spread. However, host-directed immunotherapies have emerged as promising alternative approaches to disease control and prevention ...

RSV-based Virus-like Particles as Vaccines

cowboyinnovations@okstate.edu — Thu, 12 May 2022 13:05:58 GMT

BACKGROUND Respiratory syncytial virus (RSV) is the single largest cause of viral pediatric bronchiolitis and pneumonia in the world; in 2015, 33.1 million RSV associated acute respiratory infections (ARI) in children resulted in 3.2 million hospitalizations and 59,600 deaths globally. This disease is also dangerous to people over 65 with 1.5 million RSV-ARI resulted in 336,000 hospitalizations and 14,000 deaths globally. Pursuit of a vaccine for this disease has been ongoing since the 1960s, but none have been developed. There is a critical need for a vaccine to provide protection again...

Inhibitors of the BfrB-Bfd Complex for Killing Biofilm Bacteria

cowboyinnovations@okstate.edu — Thu, 12 May 2022 13:04:40 GMT

BACKGROUND Biofilms are communities of microbes adhering to a surface and often embedded in an extracellular matrix. As a result of this structure, biofilms exhibit resistance to both host immune responses and antibiotics. Approximately 80% of human bacterial infections involve biofilms; this can take the form of chronic wound infections, chronic otitis media, osteomyelitis, recurrent urinary tract infection, endocarditis, and cystic fibrosis-associated lung infections. There is also a high incidence of biofilm-associated infections affecting indwelling catheters, orthopedic implants, st...

A Risk Index System for Evaluating Risk of Diabetic Retinopanty

cowboyinnovations@okstate.edu — Thu, 12 May 2022 13:01:47 GMT

BACKGROUND Diabetic retinopathy is a vascular condition that damages the retina as a result of diabetes mellitus, and is the leading cause of blindness in industrialized nations, and the leading cause of blindness in adults globally. The likelihood of patients developing diabetic retinopathy is very high, with almost all of Type I and more than 60% of Type II patients developing it after 20 years of having diabetes. To reduce vision loss there is a critical need to accurately screen for this serious eye condition as early as possible to allow for adequate prevention treatment and increas...

Effects of Nitrite Embed Packaging and Rosemary on Dark Cutting Beef Color

cowboyinnovations@okstate.edu — Thu, 12 May 2022 12:49:46 GMT

BACKGROUND Beef purchasing decisions are influenced by color over any other quality factor. Consumers use discoloration as an indicator of freshness and wholesomeness, associating bright red color with these qualities; any deviation from this color leads to a discounted price on beef. Nearly 15% of all retail beef ends up being sold for a discounted price due to discoloration, creating a massive economic loss. Meat color is primarily determined by myoglobin, a sarcoplasmic protein present in muscle tissue, existing in 3 redox states. The desired state, oxymyoglobin, is not as prevalent&n...

Development of Novel Biocatalytic Conversion Process for Production of Alcohols, Ketones and Organic Acids

cowboyinnovations@okstate.edu — Thu, 12 May 2022 12:44:08 GMT

BACKGROUND Subterranean mound-building termites produce the greenhouse gases carbon dioxide and methane (CO2 and CH4, respectively). For African, Australian, and South American taxa, these patterns have been well studied. However, North American termite gas emissions have not been defined in field settings, largely due to their uneven spatial distribution. Greenhouse gases are emitted out of soil from more sources than termites, and an accurate method of acquiring biogas measurements in field settings is needed to track the flux in associated biogas emission. SUMMARY OF TECHNOLOGY OSU ...

Stent Nanocoatings with Controlled Drug Release and Improved Biocompatibility

cowboyinnovations@okstate.edu — Thu, 12 May 2022 12:30:45 GMT

BACKGROUND Industrial biopharmaceutical cell culture necessitates an expensive and risky scale-up process to get production scale volumes in order to manufacture proteins and other biopharmaceutical products. Traditional stirred single-use bioreactor bags can only scale to a five-fold maximum, but scaling for production requires several thousand fold increases. For industrial production, a complex seed train of multiple disposable bags with associated equipment are needed. These production scaling practices depend on highly trained personnel working in aseptic conditions on highly specia...

Method for Computer-assisted Medical Billing Using Natural Language Processing Techniques

cowboyinnovations@okstate.edu — Thu, 12 May 2022 12:22:17 GMT

BACKGROUND Medical billing is critical to the revenue cycle management of healthcare providers; accurate and efficient billing is crucial to reimbursing healthcare providers for their services. However, current systems depend on human coders parsing through clinical summaries and notes to list treatments for billing and insurance reimbursement. Unfortunately, this is a time-consuming process prone to errors, further complicating medical billing. Existing computer-assisted systems are simple broad human-computer interactions that do not address the root problem of the complex nature of he...

3D Printing System for Vertical Construction

cowboyinnovations@okstate.edu — Thu, 12 May 2022 11:26:21 GMT

BACKGROUND Most 3D printing systems sequentially apply their layers from above. Such systems have distinct challenges when creating vertically reinforced concrete structures such as walls or columns. Most vertical reinforced concrete structures contain reinforcing bars that give the structure strength after the concrete has cracked. It is possible to use other methods of reinforcing, such as internally mixed fibers, placing reinforcement inside of previously placed concrete, or reinforcing the structure externally. Methods which do not place concrete around pre-placed reinforcement bars ...

Laser Fabrication of Multi-principal Element Alloy Nanoparticles

cowboyinnovations@okstate.edu — Thu, 12 May 2022 11:24:48 GMT

BACKGROUND In the past decade, the development of multi-principal element alloys (MPEAs), a parent domain of high entropy alloys (HEAs), has created significant interest in the materials community, particularly as structural materials due to their superior mechanical and radiation-resistant properties. MPEAs consist of multiple principal elements in the atomic lattice sites as compared to one principal and other minor alloying elements in conventional alloys. While the research of HEAs has brought several breakthroughs already, it has been largely restricted to the bulk-scale phenomena. ...

Recycling Diesel Soot Nanoparticles for Use as Activated Carbon in Li ion Batteries

cowboyinnovations@okstate.edu — Thu, 12 May 2022 11:23:37 GMT

BACKGROUND The steady increase in the consumption of fossil fuels in modern society has caused several serious environmental and human health issues. The burning of fossil fuels not only produces carbon dioxide emissions, which are contributing to global warming and poisoning the world’s oceans, but also releases toxic air-borne pollutants into the atmosphere. For example, combustion of fossil fuels in diesel engines generates nanoscale particulate matter (PM) with an aerodynamic diameter lower than 2.5 μm (ex. PM2.5). According to Global Burden of Disease report, alm...

Real Time Measurement of Moisture and Hydration of Concrete

cowboyinnovations@okstate.edu — Thu, 12 May 2022 11:12:19 GMT

BACKGROUND Concrete derives its strength from calcium silicate hydrate, a product of the hydration reaction that takes place when water is mixed with cement. A process known as curing, which involves providing continuous moisture and maintaining or providing heat to the concrete mixture, promotes the formation of calcium silicate hydrate. Curing conditions can impact the development of the calcium silicate hydrate microstructure. This in turn affects the properties of the cured concrete, such as porosity, permeability, shrinkage, creep, and strength. To optimize curing conditions, it is benef...

Small Turbojet Exhaust Nozzle with Optimal Geometry and Integrated Exit Guide Vanes

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:42:51 GMT

BACKGROUND Small scale turbojets are used for various applications amongst the military and commercial industry. Given their diverse capability, these engines need to perform at an optimal level to maintain success in their missions. The purpose of the presented design is to improve the thrust-to-weight ratio of a small turbojet engine by only modifying the nozzle. For demonstration purposes, a JetCat P100-RX turbojet engine will be used for analysis and testing. The primary challenge is to increase thrust with minimal increase in weight. Several solutions were constructed such as nozzle...

Additive Manufacturing Using Ionized Particles

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:39:03 GMT

BACKGROUND Modern 3D printers can print intricate shapes at fine detail, but their low print speed enables them to only be used for prototyping or, at best, limited batch manufacturing. As an example, the fasted current metal printers can print a volume of about 60 cm³/hr. per nozzle or laser. This equivalent to about 8 grams/minute for a stainless-steel material. Cold spray is a manufacturing technique wherein particles, usually of metal, are accelerated at supersonic velocities to impact on a substrate. The high speed of the particles causes them to cold weld onto the substrate. T...

Multifunctional Acoustic Liner for Broadband Low-Frequency Applications

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:35:42 GMT

BACKGROUND In many applications such as in the aerospace domain, multifunctional structures that provide structural integrity and conformity, and aerodynamic functions, but in addition also acoustic noise mitigation as well as thermal management functions are desired. Addressing low-frequency (<~1000 Hz) acoustic noise mitigation using lightweight, compact, extreme environment compatible liner structures is particularly challenging. Further, it is desirable that the acoustic absorption bandwidth for such liners has a broadband performance encompassing these hitherto unaddressed l...

Sliding Weather Instrument Fixed to Tether (SWIFT)

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:33:19 GMT

BACKGROUND Kite Popper Line Climber is a manually deployed and uncontrollable sail. Kite popper can travel up the kite line to a stopping point (or bridle point) where the line connects to the kite, then “pop” closed and slide back down the line. The user needs to thread the kite through the popper, open its sail, and watch as the wind carries it all the way up to a kite. When it reaches the kite, it will collapse (with the help of an elastic band) and slide back down to the user to send the popper up to the kite again SUMMARY OF TECHNOLOGY SWIFT is designed as a climbing s...

Rocket-Assisted Take-Off System Technology Demonstrator for Unmanned Aircraft

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:30:54 GMT

BACKGROUND Some unmanned aircraft applications for high-speed flight, such as aerial target drones, require a means to launch without a runway. Current methods to address this need include catapults, pneumatic launch rails and rocket-assisted take-off (RATO) systems. The use of a RATO system is often expensive but can be accomplished with a zero-length launch rail that cradles the vehicle and uses a launch footprint nearly the size of the vehicle itself. This method uses rocket motors to not only propel the vehicle forward but also lift the aircraft vertically to a desired flight path an...

Turboelectric Power and Propulsion System for Unmanned Aircraft

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:29:04 GMT

BACKGROUND Current level of technology (LOT) multi-rotor unmanned aircraft (UAS) platforms is limited in range and endurance by the inherently low energy density of current LOT batteries. With more rigorous requirements being imposed by commercial, industrial, and defense users, the UAS market is leaning heavily on hybrid systems to fill this gap. Piston based hybrid systems exist; however, they struggle to overcome issues such as cylinder wall cooling, vibration, and the ability to run on heavy fuels. Turboelectric power and propulsion systems leverage the high energy density of hydroca...

Rapid Anaplasma Detection Kit

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:26:48 GMT

BACKGROUND The tick-borne pathogens in the genus Anaplasma continues to impact livestock production in the United States and worldwide. Economic loss due to bovine anaplasmosis in the U.S., alone, is estimated to be greater than $300 million/year. While acute disease results in considerable production losses, cattle can survive the acute phase of Anaplasma marginale develop persistent life-long infection, and therefore pose risk of future outbreaks. These animals then serve as a major reservoir for biological infection and transmission by ticks and mechanical transmission by the transfer...

Using Mie Resonance Mediated Energy and Electron Transfer of Dielectric Cu2O Nanoparticles in Photocatalysis

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:22:42 GMT

BACKGROUND Photovoltaics and solar thermal collectors are most widely used for solar energy generation. Until now, this field has been dominated by photovoltaic devices, usually made of silicon, and profiting from the experience in manufacturing and material availability resulting from the semiconductor industry. Understanding the working mechanisms, one can recognize that two common limitations exist in solar utilization schemes- the limited light absorption and the rapid charge recombination in semiconductors. Some semiconductors have been explored for photocatalytic and photovoltaic applic...

Fabrication of Large Area Gold-based Metalenses

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:16:57 GMT

BACKGROUND Surface plasmons (SP) and surface plasmon polaritons (SPP) are nonlinear 36 many-body excitations that couple light with the electron density of states of a material, in 37 particulars, metals. The nonlinear nature of SP and SPP can be used for frequency doubling of 38 light (second harmonic generation) and the formation of evanescent waves that enhance 39 the Raman signature of molecules on a surface (surface enhanced Raman spectroscopy), to 40 name a few. More recently, plasmonics are being utilized in metalenses, a two-dimensional lens 41 that mitigates aberrations and stig...

Method and Implementation of Dispersion Compensation in Terahertz Wireless Signals

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:13:35 GMT

BACKGROUND A broadband, wireless terahertz signal is comprised of a multitude of individual frequency components. These frequencies travel at different speeds through the atmosphere, which causes the composite signal to spread out in time, as some frequency components arrive later than others. This is an undesirable effect known as “group delay dispersion” (GDD). Positive GDD occurs when terahertz waves propagate through the atmosphere, and this indicates that high frequencies arrive later than low frequencies. The resulting temporal broadening due to GDD distorts the received sig...

TFT-less IR-driven OLED Display

cowboyinnovations@okstate.edu — Thu, 12 May 2022 09:08:54 GMT

BACKGROUND TV screen sizes are getting bigger and bigger every year. However, manufacturers using organic light-emitting diode (OLED) technology face a big challenge in fabricating TV screens over 100 inches at reasonable cost. Unlike the OLED process which is compatible with low-cost, low-temperature, and large area processing methods including roll-to-roll printing processes, the thin film transistor (TFT) backplane used for active matrix (AM) driver circuits requires a batchto-batch vacuum process with a limited substrate size. Currently, the largest mother-glass size for a TFT backpl...

Method of Removing Oil and Heavy Metals from Petroleum Produced Water Using Microbiological Stimulation Coupled to Dolomite Filtration

cowboyinnovations@okstate.edu — Tue, 10 May 2022 12:23:21 GMT

BACKGROUND The production of conventional and unconventional oil and gas resources is accompanied by the production of large volumes of produced water (PW). PW contains high concentrations of total dissolved solids (TDS) and oil. TDS of PW includes high concentrations of toxic metals (e.g., Ba, Sr, Cd, Cr, and As). Oil includes dissolved and emulsified oil mostly composed of n-alkanes. Concentrations of n-alkanes and toxic metals in PW is orders magnitude higher than in conventional wastewater. A combination of high concentrations of n-alkanes and toxic metals does not only pose a risk to huma...

M2021-016 METHOD OF REMOVING OIL AND HEAVY METALS FROM PETROLEUM PRODUCED WATER USING MICROBIOLOGICAL STIMULATION COUPLED TO DOLOMITE FILTRATION

cowboyinnovations@okstate.edu — Tue, 10 May 2022 12:01:56 GMT

METHOD OF REMOVING OIL AND HEAVY METALS FROM PETROLEUM PRODUCED WATER USING MICROBIOLOGICAL STIMULATION COUPLED TO DOLOMITE FILTRATION (2021-016) BACKGROUND The production of conventional and unconventional oil and gas resources is accompanied by the production of large volumes of produced water (PW). PW contains high concentrations of total dissolved solids (TDS) and oil. TDS of PW includes high concentrations of toxic metals (e.g., Ba, Sr, Cd, Cr, and As). Oil includes dissolved and emulsified oil mostly composed of n-alkanes. Concentrations of n-alkanes and toxic metals in PW is...

Devon offering of A Method for Improving Critical Heat Flux

cowboyinnovations@okstate.edu — Tue, 10 May 2022 07:58:22 GMT

BACKGROUND Boiling is a phenomenon of vital importance in a broad range of industries such as power generation, desalination, chemical processing, refrigeration, and electronics thermal management. Nucleate boiling is an efficient way of transferring heat, for a given difference between the heat transfer surface and the fluid temperatures (the so-called wall superheat). Unfortunately, Boiling Crisis occurs when a vapor layer forms on a heating surface resulting in orders of magnitude reduction in the rate of boiling. This requires additional energy inputs to achieve boiling which can be detr...

Incorporation of the Horseradish Peroxidase Gene in a Viral Genome Provides a Rapid and Cost-effective in vitro Method to Determine the Antiviral Potential of Antibodies or Drugs

cowboyinnovations@okstate.edu — Thu, 07 Apr 2022 13:53:29 GMT

BACKGROUND In-vitro virus neutralization assays are an important step in determining potential in-vivo efficacy of vaccines or (synthetic) anti-viral antibodies. Most recent micro-neutralization assays are based on luciferase or fluorescence read-outs. Viruses of interest are modified by inserting genes encoding luciferase or fluorescent proteins. Following incubation of these modified viruses with antibodies of interest, virus-antibody complexes are then incubated on cells, and the success of neutralization is determined by the level of luminescence or fluorescence. Such assays are sensitive...

Modified Carbon Fiber Electrodes for Multifunctional Composites

cowboyinnovations@okstate.edu — Tue, 01 Mar 2022 08:32:27 GMT

BACKGROUND Applications of supercapacitors in the form of structural supercapacitors has been an incredibly interesting field of study in energy storage devices in the previous two decades. Supercapacitors uniquely occupy the interface of capacitors (high power density) and rechargeable batteries (high energy density). Structural supercapacitors are a form of multifunctional composites that provide both electrical storage and structural performance. In the simplest form, a multifunctional structural composite can be fabricated by combining two layers of carbon fiber pl...

High Thermal and Electrical Conductivity Polymer Composites

cowboyinnovations@okstate.edu — Tue, 01 Mar 2022 08:29:20 GMT

BACKGROUND Traditionally, metals have been used to protect against electromagnetic interference; however, their weight and machinability constraints have led to an increased usage of composites. To address the issue of low conductivity in composites, intrinsically conducting polymers or the inclusion of conductive fillers (e.g., carbon black, carbon fibers, carbon nanotubes) have been employed. Unfortunately, these materials have less shielding effect than metals, even at high volume fractions of fillers (which have an additional detriment of reducing toughness and ductilit...

Method for Deriving Minimum-Phase Source-Signature from Multi-Channel Multi-Offset Seismic Data

cowboyinnovations@okstate.edu — Fri, 11 Feb 2022 08:10:32 GMT

Method for Deriving Minimum-Phase Source-Signature from Multi-Channel Multi-Offset Seismic Data – OSU #2021-012 BACKGROUND A seismic survey is designed to image or map the subsurface of the earth by sending energy generated by a seismic source down into the ground and recording the “echoes” that return from the rock layers below. The source of seismic energy might be, for example, explosions or seismic vibrators on land or air guns in marine environments. During a seismic survey, the source is positioned at various locations near the earth's surface above a geologi...

An IgM ELISA to Detect Acute Cytauxzoonosis

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:45:50 GMT

BACKGROUND Cytauxzoonosis is a highly-fatal disease of domestic cats with limited treatment modalities and a narrow therapeutic window. This condition is common in southeastern and southcentral United States with an estimated mortality of near 100% without treatment. Records from 2014-2020 shows ~97% mortality in cases seen by the OSU Veterinary Teaching Hospital, and it is estimated that up to 4110 cats are infected with the Cytauxzoon felis each year in Oklahoma alone. Current standard of care therapies (atovaquone + azithromycin) can increase survival up to 60% in cats with cytauxzoonosis,...

RT-RPA nfo for Detection of SARS-CoV-2 in Covid-19 Specimens

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:44:46 GMT

BACKGROUND COVID-19 has caused a global pandemic. As a result, several assays and detection processes have been developed. Covid diagnostics is a huge market estimated at over $84 bn in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 3.1% from 2021 to 2027. Although there are 100s of Covid diagnostic tests being developed by companies around the world, there are very few that are RPA-based. As a result, OSU’s novel test can provide a differentiated value to COVID-19 testing laboratories and facilities, particularly those that cannot afford investing into RT-PCR...

New Class of Non-antibiotic Antimicrobial Compounds

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:43:45 GMT

BACKGROUND Emerging drug resistant and virulent bacterial strains pose a significant threat to modern clinical practice due to increasing pressure on existing antibacterial therapies and the rise in hospital and community-based infections. Multi‐drug resistant (MDR) pathogenic bacteria and fungi are now resistant to most available antibiotics and antifungals, including new generation, ceftazidime and daptomycin. Hence, there is an urgent need for the next generation of antibacterial agents. Our discovery of a new group of small molecules – cyanoximes – followed by their intensive ...

Individual Intake Hay Basket Modification for SmartFeed Units

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:41:54 GMT

Individual Intake Hay Basket Apparatus (OSU Ref # 2021-008) BACKGROUND Individualized livestock feeding systems are an indispensable facet of modern agricultural research, development, and production. However, these setups are often non-conducive to use with bulky feeding materials, such as long-stemmed hay. Research studies collecting hay intake data can decrease hay bulkiness (e.g., adding moisture, reducing particle size), but these changes to hay affect intake and do not provide an accurate representation of diets consumed in production settings. This creates a rift between re...

Tools for Visualizing and Cutting Tissue for Minimally-Invasive Surgery

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:35:20 GMT

BACKGROUND Minimally invasive surgical procedures are increasingly becoming preferred approaches for the management of various benign and malignant surgical conditions. Comparing with open surgical procedures, minimal invasive procedures face challenges in proper identification of anatomical danger zones which includes arteries, veins, ureter, bowel, bile duct, etc. As these zones are situated under the tubular structure surgeon cannot see them and have chances of injury. Recent studies have developed some probes which aims to sense the arteries using mechanical pressure changes due to pulsat...

BioGas Sampler(alternate name MetaGas Sampler, or MetaboGas Sampler)

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:33:55 GMT

NOVEL CHAMBER AND METHODS TO MEASURE BIOGAS FLUX IN FIELD AND AGRICULTURAL SETTINGS OSU 2017-054 BACKGROUND Subterranean mound-building termites produce the greenhouse gases carbon dioxide and methane (CO2 and CH4, respectively). For African, Australian, and South American taxa, these patterns have been well studied. However, North American termite gas emissions have not been defined in field settings, largely due to their uneven spatial distribution. Greenhouse gases are emitted out of soil from more sources than termites, and an accurate method of acquiring biogas measurements in fiel...

Preparation of Melanin-inspired Antimicrobials

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:32:08 GMT

BACKGROUND Bacterial resistance to antibiotics is a serious worldwide health problem, which presents the risk of increased infection and uncontrolled transmission. Antibiotic resistance due to the misuse of drugs has genetically selected for the survival of resistant bacterial strains. This renders established antibiotic treatments ineffective against these strains, consequentially increasing mortality rates as well as economic costs. Methicillin resistant Staphylococcus aureus (MRSA) is an infection caused by a type of staph bacteria resistant to many antibiotics. The Centers for Disease Con...

Engineering Mesenchymal Stem Cells for COPD Therapy

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:30:40 GMT

Engineering Stem Cells for Pulmonary Disease Therapy OSU 2016-003 and 2016-004 BACKGROUND The discovery of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have resulted in a plethora of opportunities to produce tissue-specific cell types for disease modeling, drug screening and treatments for diseases. For pulmonary diseases such as COPD, stem cells have been a proposed strategy to repair damaged lungs. However, these studies have yielded controversial results. Additional research has demonstrated that transplantation of alveolar epithelial cells (AECs) hold gre...

Engineered Respiratory Syncytial Viruses with Control of Cell-to-Cell Virus Transmission for Enhanced Safety of Live Virus Vaccines

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:28:21 GMT

ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES FOR SAFE LIVE VIRUS VACCINES (OSU Ref # 2011-036) BACKGROUND Respiratory Syncytial Virus (RSV) is the largest viral cause of pediatric bronchiolitis worldwide, a respiratory disease that results in over 100,000 deaths per year. RSV can also cause adult lung diseases such as pneumonia and poses a serious risk for the elderly and the immunocompromised. Unfortunately, a vaccine for RSV is not currently available. Although, live-attenuated (weakened) RSV virus offers the most promise for a future vaccine, previous and current efforts hav...

Removing Phosphorus from Surface and Drainage Waters

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:25:22 GMT

BACKGROUND Transport of phosphorus (P) to surface waters is one of the main causes of eutrophication. A significant source of this P is non-point transport from agriculture, horticulture, urban and suburban land through surface runoff. This occurs in the form of particulate P and dissolved P. Particulate P (i.e. P adsorbed onto soil particles) losses occur as soil is lost through erosion processes. This form of P loss is controlled with several best management practices (BMPs) that prevent erosion such as buffer strips or riparian zones. However, these BMPs have little or no effect on prevent...

Method for fabrication of high dispersion polymer nanocomposites

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:24:45 GMT

IMPROVED FORMATION OF HIGH DISPERSION POLYMER NANOCOMPOSITES OSU 2013-049 BACKGROUND Polymers, molecules composed of repeated subunits, are the building blocks for many materials including synthetic plastics, rubber, and nylon. Polymer nanocomposites (PNCs) are polymers with nanofillers (nanoparticles) dispersed throughout the polymer's matrix. Addition of the nanofillers greatly improves the physical properties of the polymer such as strength, stiffness, dimensional stability, wear resistance, fire retardance, and conductivity. Unfortunately if the nanofillers are not dispersed evenly t...

Nanowire-Nanoparticle Conjugate Photolytic Fuel Generators

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:23:41 GMT

Background Conversion of sunlight to chemical fuels by artificial photosynthesis has been a long-sought goal. In particular, significant research activity was stimulated towards photolytic cells producing hydrogen in 1972, when Fujishima and Honda demonstrated water could split to hydrogen and oxygen under sunlight (photolysis) using an n-type TiO2 electrode. Although nanostructured TiO2 photolytic cells exploiting high surface to volume have recently been demostrated, unfortunately TiO2 can absorb only the ultravoilet portion of the sunlight due to its large band gap. Numerous efforts to inc...

Combining site-directed mutations and reconstitution with a locked chromophore analog converts photoactive yellow protein into a highly fluorescent protein tag

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:22:10 GMT

CONVERTION OF PHOTOACTIVE YELLOW PROTEIN INTO A HIGHLY FLUORESCENT PROTEIN TAG BACKGROUND Fluorescent protein tags, such as green fluorescent protein (GFP), exhibit fluorescence when viewed under ultraviolet light. Since these tags make it possible to 'see' metabolic interactions, attaching them to proteins, antibodies, and amino acids allows researchers to study interactions between biomolecules and thus improve our understanding of such diverse biological processes as those involved in brain functionality, specific protein-protein interactions, and the spread of disease. Although G...

Lightweight Green Roof Media

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:21:20 GMT

2012-027 - Lightweight Green Roof Media Less expensive than conventional green roof soil media Weighs 50% less than conventional soil media Can be retrofitted onto existing buildings Abstract This cost-effective new soil media consists of a nutrient-rich composition that weighs 50% less than typical green roof soil media on the market. The lightweight nature of this soil media allows buildings to be retrofitted to support green roofs without negatively affecting the existing infrastructure. Additionally, the soil mixture is so fertile that it can be used as potting soil and...

Moldable Wood

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:20:33 GMT

BACKGROUND Advances in wood-plastic-composites (WPC) have permitted the utilization of wood in additional applications such as automotive components, household electronics, and environmentally resistant building products. By combining the mechanical strength of wood with the durability and resistance of plastics, WPC has several distinct characteristics that make it environmentally friendly while requiring little maintenance. Strides in this field have been made in its moldability, maintenance, and resistance. However, there is still a need for WPC to display strength, stiffness, and rigidity...

Metabolites of SHetA2 as Anti-Cancer Agents

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:19:06 GMT

BACKGROUND SHetA2 has previously been identified by OSU researchers as a strong anti-cancer agent that induces apoptosis (cell death) in 8 different types of kidney cancer cells and is being developed for treatment of Polycystic Kidney Disease (PKD). SHetA2 is in the final stages of preclinical testing and since no toxicity to normal cells has been observed by National Cancer Institute (NCI) in trials with mice, rats, and dogs, clinical trials will begin on human patients in the near future. SUMMARY OSU researchers have identified and synthesized a major metabolite (active molecule) of SHet...

Use of the Salmonella spp type III secretion proteins as protective vaccine candidate

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:17:59 GMT

BACKGROUND Bacterial species belonging to the genus Salmonella are the leading cause of foodborne illness worldwide, inducing approximately 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths in the U.S. annually. Unfortunately, researchers have encountered several roadblocks in the quest for a safe, effective means of treating or preventing Salmonella infections: â?¢ Large scale monitoring for Salmonella in food products is impracticable â?¢ Rising antimicrobial resistance is making treatment of Salmonella infections increasingly problematic â?¢ Cu...

Method and Device of Identifying and Evaluating Neurovascular Structure

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:17:16 GMT

BACKGROUND A radical prostatectomy is an operation to remove the prostate gland and some of the tissue around it. The cavernous nerves, which are responsible for erection and are a part of the prostatic neurovascular bundle (NVB), travel very close to the prostate gland and, because the nerves are difficult to identify visually and current locating devices are inadequate, may be injured during the prostatectomy. Injury of the NVB is found in over half of prostatectomy patients experiencing erectile dysfunction 18 or more months after surgery. Therefore, identifying and avoiding damage to the ...

Geospatial Logistics and Agricultural Decision Integration System (GLADIS)

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:15:41 GMT

BACKGROUND Eastern Redcedar is an invasive tree that is economically and ecologically damaging to the state of Oklahoma. For this raw material, and others like it, there is limited entrepreneurial interest for the utilization of this natural resource. This is often due to the lack of data regarding the true cost of the processes required for successful utilization. Thus, it would prove beneficial if there was a way to determine which industries could be implemented to derive maximum economic profit from these materials. By providing a platform to evaluate the worth of these untapped resources...

Textile repurposing and sustainable garment design

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:11:44 GMT

BACKGROUND Occupying nearly 5% of all landfill space, textile waste (e.g., clothing, footwear, accessories, carpets, towels, bedding, drapery) has continued to make a negative impact on our environment. A variety of textile recycling methods have been developed that convert discarded textile fibers into raw materials (e.g., yarn, fibers, polymer chips). Current processes to recycle textiles, such as those employed by Giotex, are time consuming and burden the environment by employing energy intensive processes. Another approach has been given to sustainable garment design and production to red...

Method and component of a novel antiviral targeting type 1 interferon response

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:09:34 GMT

BACKGROUND Influenza virus infection results in 200,000 hospitalizations, 36,000 deaths, and $87 billion in healthcare costs per year in the U.S. The current treatments, which consist of antiviral drugs that target viral proteins, only work if new strains of influenza virus do not emerge. However, influenza viral proteins readily mutate to create new, drug resistant viruses--rendering antiviral drugs useless. Thus, there is a critical need to develop improved anti-influenza medicines that are effective regardless of virus changes and mutations. SUMMARY OF TECHNOLOGY OSU researchers discover...

Cofactor-free, Inexpensive, Rapid Liver Microsomal Bioreactor for Examining Drug Metabolism and Inhibition and Green Synthesis of Drug Metabolites

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:09:04 GMT

BACKGROUND Liver microsomes (LMs) are useful for biosensing, catalytic applications and drug development because of their ability to catalyze a broad range of reactions with inherent stereoselectivity. Using traditional LMs, expensive cofactors, such as NADPH must be added to facilitate metabolic reactions. Previous researchers have demonstrated that electrocatalysis can replace the need for adding NADPH in LMs. However, achieving highly enhanced electrocatalytic metabolite production from a simple adsorption of LM directly onto a structure with sufficient electrocatalytic stability and reusa...

Novel Cleaning-In-Place Meat Grinder Sanitization Process

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:08:38 GMT

BACKGROUND An estimated 60% of all retail beef sales are in the form of ground beef, which is notoriously associated with foodborne pathogen outbreaks. There are existing protocols and control points in meat processing or retail operations, which specify the frequency and proper procedures for grinder sanitization. Current industry protocol is to dissemble and then clean meat grinders at the end of a shift. However, if contamination occurs between two cleaning operations, large amounts of product could be contaminated and subject to recall. An increase in the frequency...

Engineering Induced Pluripotent Stem Cells for COPD Therapy

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:08:08 GMT

BACKGROUND The discovery of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have resulted in a plethora of opportunities to produce tissue-specific cell types for disease modeling, drug screening and treatments for diseases. For pulmonary diseases such as COPD, stem cells have been a proposed strategy to repair damaged lungs. However, these studies have yielded controversial results. Additional research has demonstrated that transplantation of alveolar epithelial cells (AECs) hold great promise to repair damaged lungs for pulmonary diseases, including COPD. However, t...

Tissue Repair Devices and Scaffolds

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:07:18 GMT

BACKGROUND In orthopedics, it is often necessary to repair or replace damaged or degenerating bone. Multiphasic, three-dimensionally printed, tissue repair device (M3DRD) scaffolds have emerged as a replacement to current bone grafting techniques, all of which have serious drawbacks and cannot be produced in the elaborate designs and shapes necessary to repair complex bone defects. M3DRDs can be custom produced for every type of orthopedic bone repair. The scaffolds facilitate the regeneration of bone by providing a structure for cells to attach to and an environment conducive to new tissue f...

Methods for Detecting Biofilm In-Situ from Seismic Data

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:04:57 GMT

BACKGROUND Formation of biofilms is a predominant way of life for most microorganisms in the environment. Biofilms comprise extracellular polysaccharides (EPS), which is a gel type material playing a vital role in attachment of microbial cells to growth surfaces. Biofilms are quintessential byproducts of hydrocarbon degradation. Thus, their detection could be critical in assessing environmental remediation, carbon sequestration, and enhanced oil recovery. However, in-situ detection of biofilms in field conditions has remained an unresolved problem. SUMMARY OF TECHNOLOGY OSU researchers have...

Antimicrobial, thermally and visible light stable silver (I) cyanoximates that inhibit biofilm formation

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:03:41 GMT

BACKGROUND Hospital-acquired infections are becoming more prevalent worldwide. According to the CDC, 1.7 million patients in the US acquire infections during their hospital stay, which costs $6.7 billion dollars annually. Fifty-four percent of hospital-acquired infections occur at surgical sites or in urinary tracts, and are increasingly caused by antibiotic resistant bacteria. Incorporating long lasting broad-spectrum antibacterial agents into the polymeric matrix for fixing indwelling medical devices has the potential to greatly reduce the number of hospital-acquired infections. SUMMARY OF...

BOVINE VIRAL DIARRHEA VIRUS (BVDV) SUBTYPE 2b GROWN IN BOVINE MONOLAYER CELL CULTURES AS A CYTOPATHIC (CP) STRAIN FOR VACCINE PRODUCTION, DIAGNOSTIC TESTING, AND SEROLOGY

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:02:33 GMT

BACKGROUND BVDV is the most costly disease in the cattle industry, estimated at around 2 billion per year. Often without visible symptoms, this disease inhibits conception, causes spontaneous abortion and birth defects, and hinders the immune system. BVDVb1 is the predominant source of persistently infected (PI) cattle, and there is a growing prevalence of BVD2b. Unfortunately, few vaccines exists that adequately protect against BVDV1b, and current practice does not vaccinate for type 2b. SUMMARY OF TECHNOLOGY Dr. Robert Fulton at Oklahoma State University has isolated cytopathic BVDV subty...

BOVINE VIRAL DIARRHEA VIRUS (BVDV) SUBTYPES 1a, 1b, AND 2a GROWN IN BOVINE MONOLAYER CELL CULTURES AS CYTOPATHIC (CP) STRAINS FOR VACCINE PRODUCTION, DIAGNOSTIC TESTING, AND SEROLOGY

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:02:03 GMT

Isolation of bioactive compounds from Tremella spp.

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 13:00:01 GMT

BACKGROUND Since the beginning of the 21st century, fungi have been known for their extraordinary medicinal qualities. Tremella spp. is a yeast-like fungus that has been conventional utilized for pharmaceuticals and is still being explored for additional medicinal properties. Of particular interest are its extracellular polysaccharides (exopolysaccharides) which have been associated with the enhancement of the immune system in humans. Though improvements have been made in the growing process of Tremella, researchers are actively working to optimize processes for growing, producing, and isolat...

ViLDAR (Visible Light Detection and Ranging): A Novel Speed Estimation System using Visible Light in Vehicles

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:55:00 GMT

SPEED ESTIMATION, DETECTION AND RANGING USING VISIBLE LIGHT IN VEHICLES (OSU # 2017.58) OSU researchers have developed an advanced method named ViLDAR (Visible Light Detection and Ranging). In this method, the speed of a vehicle is detected using the vehicle’s LED headlight intensity information acquired by a photo-detector (PD) (Figure 1). The experimental results show that ViLDAR method outperforms the traditional RADAR/LiDAR methods (that uses radio frequencies (RF) or laser signals) in speed accuracy for a wide range of incidence angles between vehicle and PD (Figure 2). ...

Nanodiamond Process Technology Development for Thermal Management of Power Electronics

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:50:47 GMT

2015-010 - Nanodiamond Process Technology Development for Thermal Management of Power Electronics Novel method for depositing nanocrystalline diamond thin layers Heat dissipation from the device layer rather than through the substrate Especially valuable for Wide Band Gap materials such as GaN and SiC Abstract This invention is a novel nanocrystalline diamond (NCD) seeding and process technology which enables the direct extraction of heat from power devices such as GaN, SiC which operate at high current densities requiring rapid heat dissipation. The method comprises seedin...

Bacteriophages to control Shigatoxigenic Escherichia coli

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:43:13 GMT

2015-037 - Bacteriophages to control Shigatoxigenic Escherichia coli Effective either singly or in combination against multiple strains of STECs High lytic activity across multiple STEC strains Long shelf life Background Shigatoxigenic E. coli (STEC) is a major contributor to one in six Americans becoming sick due to a foodborne illness each year. Current methods often employ harsh chemical interventions to reduce STECs and are not optimally effective. From 2009-2013, 35% of 75 foodborne illness outbreaks in ground beef were due to STECs. Clearly t...

Sonosensitized Cancer Immunotherapy with Nanoparticles

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:35:58 GMT

SYSTEM AND METHOD FOR SONOSENSITIZED CANCER IMMUNOTHERAPY WITH NANOPARTICLES (OSU Ref # 2018-009) BACKGROUND The ability of the immune system to recognize, attack, and eliminate tumors is well established. However, several tumor types (such as, but not limited to, melanoma, pancreatic, and breast tumor types) manifest a variety of immunosuppressive mechanisms to evade immune attack. As such, reversing the protective immune suppression mechanisms and stimulating immune cell activation is the fundamental goal of cancer immunotherapy. Local activation of immunogenic cell death (...

Estimation of the Age of Body Fluid Stains using RNA Degradation and a Novel qPCR Approach

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:33:56 GMT

A NEW METHOD AND KIT FOR ESTIMATION OF THE AGE OF BODY FLUID STAINS UTILIZING RNA DEGRADATION AND qPCR TECHNIQUES (OSU Ref # 2018-004) BACKGROUND Forensic laboratories frequently quantitate the amount of human genomic DNA recovered from evidentiary biological fluid samples. Additionally, forensic experts are often called into court to testify as to when a particular biological fluid sample was deposited at a crime scene. The time of deposit of a biological fluid sample remains a critical component of DNA experts’ testimonies. Current methods for quantifying and/or estimating the age o...

Chemothermal ablation of reproductive organs

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:29:10 GMT

NON-INVASIVE STERILIZATION FOR ENHANCING ANIMAL PRODUCTION, PROTECTION, AND WELLBEING (OSU Ref # 2018-007) BACKGROUND Sterilization is routinely performed in male farm animals to prevent aggressive behavior and unwanted pregnancies, avoid of prorogation of inferior genetic traits and enhance meat quality. Several studies have also demonstrated a strong impact of animal stress and pain associated with castration on weight gain. In farm animals, the most commonly used castration methodologies include open surgery and banding with an elastrator rubber ring. Although these techniques d...

A safe, self-limited, live RSV vaccine expressing pre-fusion conformation - stabilized fusion protein, and inducing both humoral and cellular anti-RSV immunity

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:14:53 GMT

A SELF-LIMITED LIVE RSV VACCINE INDUCING ANTI-PRE-FUSION F ANTIBODIES BACKGROUND Respiratory Syncytial Virus (RSV) is the single largest viral cause of pediatric bronchiolitis and pneumonia, with a high worldwide mortality, and there is no safe and effective vaccine. Ever since the encounter with vaccineenhanced disease (VED) during a formalininactivated RSV vaccination trial in the 1960s, it has been enormously challenging to impart both sufficient safety and efficacy in a single vaccine. RSV contains a negative-sense, single-stranded RNA genome that expresses eleven known pr...

CHROMAN AND TETRAHYDROQUINOLINE-DERIVED HETEROAROTINOIDS AS AGENTS TO TREAT HUMAN OVARIAN CANCER

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 11:00:21 GMT

BACKGROUND Advanced stage malignant ovarian cancer (MOC) is an incurable disease of women, resistant to chemotherapies with agents such as cisplatin, carboplatin and taxane. MOC chemotherapies also have limited tumor specificity and cause significant toxicity, resulting in modest efficacy and recurrence in greater than 70% of treated patients. Thus, there is a critical need to overcome the conventional chemotherapy barriers, and develop new means to treat and prevent recurrence of ovarian cancers, while minimizing adverse side effects to patients. Our group’s previous discovery ...

Noncontact Vitals Monitoring Using Visible Light Sensing (VLS)

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 10:58:34 GMT

SYSTEM AND METHOD OF NONCONTACT VITAL SIGNS MONITORING THROUGH LIGHT-WAVE SENSING (OSU Ref # 2018-005) BACKGROUND Monitoring human body vitals is critical for accurate diagnosis of diseases and for deciding appropriate treatment and/or therapy methods. In particular, respiration rate and heart rate are of importance for heart and lung diseases. Many vitals monitoring systems have been introduced to get the most accurate results using either contact- or noncontact-based approaches. Although many state-of-the-art systems for the vital signs measurements are based on contact se...

IncRNA FENDRR Exhibits Anti-fibrotic Activity in Pulmonary Fibrosis

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:57:19 GMT

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a fatal fibrotic lung disease characterized by a progressive decline in lung function that is chronic and fatal. The only treatment option shown to significantly extend life in a patient with IPF is a lung transplant, which only provides a ~40% survival rate 5 years post-operation. IPF usually occurs in people between the ages of 50 and 70, affecting approximately 200,000 individuals and causing 40,000 annually in America each year. Unfortunately, limited knowledge of pathogenesis of IPF has resulted in a lack of effective treatments to halt, ...

Electrochemical Paper Assay for Ultra-low Detection of Molecules in Complex Matrices

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:57:03 GMT

SYSTEM AND METHOD OF ELECTROCHEMICAL PAPER ASSAY FOR ULTRA-LOW DETECTION OF MOLECULES (OSU Ref # 2019-029) BACKGROUND Rapidly growing diabetic disorders and associated health complications highlight the need for developing new user-friendly affordable biosensors that can improve the patient care. Glucose sensors and insulin monitoring devices that help with regulating normal glucose metabolism have gained considerable attention. New electrochemical detection platforms are cost-effective and amenable to miniaturization, and thus provide the possibility to fulfill point-of-care needs for ...

Multi-chamber single use bioreactor

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:47:04 GMT

Methods of Making and Using Zwitterionic Hydrogel Beads for Protein Therapy and Protein Immobilization

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:41:37 GMT

ZWITTERIONIC MICROSCALE HYDROGELS FOR PROTEIN ENCAPSULATION/RELEASE, STABILIZATION, AND IMMOBILIZATION (OSU Ref # 2020-006) BACKGROUND Proteins are incredibly useful in medicine and industrial chemistry. Many of the most recent breakthroughs in cancer therapy are based on monoclonal antibody treatments. Yet, there are major difficulties that can act as deterrents in developments of such therapies. Similarly, usage of proteins as enzymes is limited by poor stability, short half-life, and difficulties with reusability. With growing usage of proteins as pharmaceuticals and biocatalysts, and app...

Door Traffic Counter System

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:39:36 GMT

2021-003 - Door Traffic Counter System Mechanism for library employees to easily count / track people entering and exiting the library building There are two types of roles user and administrator. Benefit Door Traffic Counter System is a web application providing a mechanism for library employees to easily count / track the number of users entering and exiting the library building. The application also allows for real‐time display of capacity information. Other Available at: https://github.com/okstate-library/door-traffic-counter License: © 2020 Board of Regents fo...

Peristaltic Mechanism for Compression of Compressible Fluids

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:39:12 GMT

2019-028 - Peristaltic Mechanism for Compression of Compressible Fluids Valve-less compressor Peristaltic compressor Linear, semi-cylindrical chamber Benefit This novel peristaltic compressor has fewer opportunities for energy loss, due to its valve-less design. Further, since it is linear, rather than rotational, additional energy savings can be realized. This could result in high efficiency refrigerators and HVACs Market Application In the refrigeration and HVAC industries Publications 25th International Compressor Engineering Conf at Purdue 2020, Session 1303 &q...

Process for Making Silicon-based Anode for Li-Ion Battery

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:38:45 GMT

2017-025 - Process for Making Silicon-based Anode for Li-Ion Battery Si-based Li-ion anode has 1000 mAh/g capacity vs 372 mAh/g for graphite Si-based Li-ion anode had 99.5% coulombic efficiency Use of polycrystalline Si allows low cost production Abstract Conventional Li-ion batteries use graphite anodes, which have a theoretical specific capacity of 372 mAh/g, which limits their application for high capacity energy storage devices. Silicon has been tried because of its high theoretical specific capacity (on the order of 4200 mAh/g) but the stress created due to volume expa...

Lithium Ion Battery Anode Containing Carbon Coated Silicon and Production Process

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:38:14 GMT

2019-006 - Lithium Ion Battery Anode Containing Carbon Coated Silicon and Production Process Si-based anode, produced with this method, has a specific capacity of 750 mAh/g at current density of 6 A/g Si-based anode, produced with this method, performs well a up to 60 degrees C When tested in a full cell, the Si-based anode displayed stable reversible capacity of 76mAh/g after 100 cycles Abstract A facile route to suppress the capacity fading because of the pulverization and uncontrolled growth of solid electrolyte interphase in silicon anodes is described. In this new appr...

A Method for Dissolved Gas Separation

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:37:52 GMT

Surfaces are engineered to be non-wetting, by coating with hydrophobic material for aqueous solutions Surfaces are engineered to be non-wetting by coating with an oleophobic material for non-polar hydrocarbon based fluids Benefit By using non-wetting coating materials, bubble nucleation is enhanced. Once bubbles are formed, they can be eluted easily from the solution. Engineered surfaces can also suppress bubble nucleation, thereby causing supersaturation of the gas in the fluid. Market Application Separation of natural gas from oil during refining. Ethanol production for f...

A Method for Improving Critical Heat Flux

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:37:19 GMT

A Method for Improving Critical Heat Flux (2019-004) BACKGROUND Boiling is a phenomenon of vital importance in a broad range of industries such as power generation, desalination, chemical processing, refrigeration, and electronics thermal management. Nucleate boiling is an efficient way of transferring heat, for a given difference between the heat transfer surface and the fluid temperatures (the so-called wall superheat). Unfortunately, Boiling Crisis occurs when a vapor layer forms on a heating surface resulting in orders of magnitude reduction in the rate of boiling. This requires additio...

Branched scissor linkage and associated auxetic mechanisms

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:37:03 GMT

2017-029 - Branched scissor linkage and associated auxetic mechanisms Branched variants of the scissor mechanism but with multiple arms Multiple arms, joined by a branched rivet allows 3D movement Benefit The scissor mechanism variant allows for nearly infinite shapes and structures. The structures can be collapsed into a compact shape then deployed into a large, functional shape. One embodiment is an extendable, grasping device. Market Application Toy market. Space applications where compactness is important for lift off, but then deployment of a larger shape with structu...

Preparation of Conductive Organic Theads as Non-metallic Interconnects

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:36:59 GMT

Highly conductive threads made from common textiles Coated threads are stronger and tougher and highly conductive Lower resistivity means the conductive threads don't get hot under electrical load Abstract The preparation of organic conductive threads comprised of highly conjugated polymer/carbon nanotube nanocomposites on a fiber thread like cotton, wool, etc, for electrical interconnects in smart clothing for enhanced reuseability and comfort. The organic conductive fiber/thread is unique in that it opens the door for all textile-based devices and sensors that can be k...

Omniphobic Coatings for Surface Treatment

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 09:35:18 GMT

2019-027 - Omniphobic Coatings for Surface Treatment This method for coating fabrics with omniphobic chemicals produces fabrics that retain the coating much longer The method is solventless and therefore more environmentally friendly Since the coating is less than 1 micron thick it allows the fabric to retain breathability Abstract This invention is a method of 3D coating of fabrics at submicron thicknesses with PFAS to produce omniphobic (both hydro- and oleo-) fabrics in a more efficient and environmentally friendly manner. Fabrics coated using the inventive method mainta...

Machine Learning-Enabled Accelerated Discovery of High Conductivity Ionic Liquids

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 06:30:20 GMT

2021-006 - Machine Learning-Enabled Accelerated Discovery of High Conductivity Ionic Liquids Background Ionic liquids are a class of salts that are liquid at room temperature with several unique and desirable properties such as negligible vapor pressure, environmentally friendly, high thermal and electrochemical stability. Because of these favorable properties, ionic liquids are currently considered a potential replacement for conventional organic electrolytes in Li-ion batteries. However, a significant limitation of ionic liquids is their sluggish transport properties limiting their widespr...

An Efficient Algorithm to Calculate a Covariance Semblance Coefficient for High Resolution Seismic Velocity Spectra

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 06:24:16 GMT

BACKGROUND The ability to accurately estimate seismic velocity is vital to accurate, common depth point (CDP) processing and seismic interpretation for structural interpretation and even more so for stratigraphic interpretation. Calculating the velocity spectra using the conventional semblance coefficient is still the predominant method even though this approach does not have the resolving power of subspace methods. This fast-covariance invention provides a nearly noise-free estimate identical to the standard spatial covariance estimate from subspace methods for the semblance coefficient wit...

OklaDrought

cowboyinnovations@okstate.edu — Tue, 08 Feb 2022 06:20:53 GMT

SOIL MOISTURE EVAPOTRANSPIRATION INDEX - (OSU Ref # 2020-034) BACKGROUND Droughts are a recurrent feature of Oklahoma's climate, and agriculture is one of the largest sectors in the state that is affected by drought events. Drought monitoring helps growers and policymakers make necessary arrangements to reduce the impact of drought and provide them with sufficient time to implement the contingency plans duly. Drought severity is computed using drought indices, which are based on environmental data. According to the World Meteorological Organization, most of the drought indices do no...