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RSV-based Virus-like Particles as Vaccines

BACKGROUND Respiratory syncytial virus (RSV) is the single largest cause of viral pediatric bronchiolitis and pneumonia in the world; in 2015, 33.1 million RSV associated acute respiratory infections (ARI) in children resulted in 3.2 million hospitalizations and 59,600 deaths globally. This disease is also dangerous to people over 65 with 1.5...

Published: 5/17/2022 | Updated: 5/12/2022 | Inventor(s): Antonius (Tom) Oomens

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Category(s): Technology Classifications > Biotech & Pharmaceutical

A Risk Index System for Evaluating Risk of Diabetic Retinopanty

BACKGROUND Diabetic retinopathy is a vascular condition that damages the retina as a result of diabetes mellitus, and is the leading cause of blindness in industrialized nations, and the leading cause of blindness in adults globally. The likelihood of patients developing diabetic retinopathy is very high, with almost all of Type I and more than...

Published: 5/17/2022 | Updated: 5/12/2022 | Inventor(s): William Paiva, Tieming Liu, Ru Wang, Zhuqi Miao

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Category(s): Technology Classifications > Software, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Medical Device & Diagnostic

Rapid Anaplasma Detection Kit

BACKGROUND The tick-borne pathogens in the genus Anaplasma continues to impact livestock production in the United States and worldwide. Economic loss due to bovine anaplasmosis in the U.S., alone, is estimated to be greater than $300 million/year. While acute disease results in considerable production losses, cattle can survive the acute phase...

Published: 5/12/2022 | Updated: 5/12/2022 | Inventor(s): Francisco Ochoa Corona, Bruce Noden

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Category(s): Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Medical Device & Diagnostic

Incorporation of the Horseradish Peroxidase Gene in a Viral Genome Provides a Rapid and Cost-effective in vitro Method to Determine the Antiviral Potential of Antibodies or Drugs

BACKGROUND In-vitro virus neutralization assays are an important step in determining potential in-vivo efficacy of vaccines or (synthetic) anti-viral antibodies. Most recent micro-neutralization assays are based on luciferase or fluorescence read-outs. Viruses of interest are modified by inserting genes encoding luciferase or fluorescent proteins....

Published: 5/12/2022 | Updated: 4/7/2022 | Inventor(s): Pramila Lamichhane, Antonius (Tom) Oomens

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Biotech & Pharmaceutical

An IgM ELISA to Detect Acute Cytauxzoonosis

BACKGROUND Cytauxzoonosis is a highly-fatal disease of domestic cats with limited treatment modalities and a narrow therapeutic window. This condition is common in southeastern and southcentral United States with an estimated mortality of near 100% without treatment. Records from 2014-2020 shows ~97% mortality in cases seen by the OSU Veterinary Teaching...

Published: 5/12/2022 | Updated: 2/8/2022 | Inventor(s): Yun-Fan Kao, Mason Reichard, Shannon Cowan, Craig Miller

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Category(s): Technology Classifications > Medical Device & Diagnostic, Technology Classifications > Biotech & Pharmaceutical, Technology Classifications > Animal Health

New Class of Non-antibiotic Antimicrobial Compounds

BACKGROUND Emerging drug resistant and virulent bacterial strains pose a significant threat to modern clinical practice due to increasing pressure on existing antibacterial therapies and the rise in hospital and community-based infections. Multi‐drug resistant (MDR) pathogenic bacteria and fungi are now resistant to most available antibiotics and antifungals,...

Published: 5/12/2022 | Updated: 2/8/2022 | Inventor(s): Nikolay Gerasimchuk, Kevin Pinks, Karen Wozniak, Marianna Patrauchan

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Category(s): Technology Classifications > Biotech & Pharmaceutical

Preparation of Melanin-inspired Antimicrobials

BACKGROUND Bacterial resistance to antibiotics is a serious worldwide health problem, which presents the risk of increased infection and uncontrolled transmission. Antibiotic resistance due to the misuse of drugs has genetically selected for the survival of resistant bacterial strains. This renders established antibiotic treatments ineffective against...

Published: 5/12/2022 | Updated: 2/8/2022 | Inventor(s): Santosh Adhikari, Toby Nelson

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Chemistry, Technology Classifications > Biotech & Pharmaceutical

Engineering Mesenchymal Stem Cells for COPD Therapy

Engineering Stem Cells for Pulmonary Disease Therapy OSU 2016-003 and 2016-004 BACKGROUND The discovery of mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs) have resulted in a plethora of opportunities to produce tissue-specific cell types for disease modeling, drug screening and treatments for diseases. For pulmonary diseases...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Li Zhang, Lin Liu

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Engineered Respiratory Syncytial Viruses with Control of Cell-to-Cell Virus Transmission for Enhanced Safety of Live Virus Vaccines

ENGINEERED RESPIRATORY SYNCYTIAL VIRUSES FOR SAFE LIVE VIRUS VACCINES (OSU Ref # 2011-036) BACKGROUND Respiratory Syncytial Virus (RSV) is the largest viral cause of pediatric bronchiolitis worldwide, a respiratory disease that results in over 100,000 deaths per year. RSV can also cause adult lung diseases such as pneumonia and poses a serious risk...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Antonius (Tom) Oomens

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

Metabolites of SHetA2 as Anti-Cancer Agents

BACKGROUND SHetA2 has previously been identified by OSU researchers as a strong anti-cancer agent that induces apoptosis (cell death) in 8 different types of kidney cancer cells and is being developed for treatment of Polycystic Kidney Disease (PKD). SHetA2 is in the final stages of preclinical testing and since no toxicity to normal cells has been...

Published: 4/19/2022 | Updated: 2/8/2022 | Inventor(s): Doris Benbrook, Richard Bunce, Kenneth Berlin

Keywords(s): Biotech & Pharmaceutical

Category(s): Technology Classifications > Biotech & Pharmaceutical

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